SKIN HOMOGRAFTS: TOLEROGENIC VERSUS IMMUNOGENIC INFLUENCES IN MICE
نویسندگان
چکیده
منابع مشابه
Skin Homografts: Tolerogenic versus Immunogenic Influences in Mice
In strain combinations involving multiple non-H-2 disparities, neonatal skin grafts may survive significantly longer than adult grafts of similar genotype on normal adult hosts, and repeatedly outlive grafts of adult origin on immunosuppressed recipients. Moreover, newborn grafts of long-standing may render their hosts unresponsive to adult skin grafts from the same donor strain. With some H-2-...
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Acquired tolerance to CBA skin homografts is lost in a large number of C3H mice neonatally injected with CBA spleen cells. The skin homografts persist for at least 2 months but then exhibit a chronic rejection pattern which may last up to 7 months. Histological analysis of the lymphoid tissues reveals the onset of an immune response in the axillary lymph nodes of many 4-month-old tolerant mice....
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Dendritic cells (DC) are sentinels of immunity, essential for homeostasis of T cell-dependent immune responses. Both functions of DC, initiation of antigen-specific T cell immunity and maintenance of tissue-specific tolerance originate from distinct stages of differentiation, immunogenic versus tolerogenic. Dependent on local micro milieu and inflammatory stimuli, tissue resident immature DC wi...
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The effect of methylcholanthrene (MC) on the survival of skin homografts was studied in various donor/host combinations. In systems where there was a strong antigenic difference involving the histocompatibility-2 (H-2) locus, MC did not influ ence the survival of the skin grafts. In weaker (non-H-2) antigenic systems the sur vival of the skin was prolonged in animals grafted shortly before, at ...
متن کاملCross-reactions to skin homografts in man.
A considerable array of evidence has been secured to suggest that the tempo and intensity of the host's immune response to tissue transplants are conditioned by the degree of histocompatibility existing between the individuals studied (1-4). Although this subject has received a great deal of attention in animal species, it has not been studied extensively in man (5-7). The present report is con...
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ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1971
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.133.4.921